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Ultrasensitive particles offer new way to find cancer (MIT)

About 10 years ago, scientists discovered a new type of genetic material
called microRNA, which appears to turn genes on or off inside a cell. More
recently, they found that these genetic snippets often go haywire in cancer
cells, contributing to tumors’ uncontrollable growth.

A team of researchers at MIT has now engineered a way to detect abnormal
microRNA levels in the blood of cancer patients, raising the possibility of
developing a simple blood test to diagnose or monitor the disease.

The technology, described in two recent papers in the journals _Analytical
Chemistry_ and _Angewandte Chemie_, consists of an array of tiny particles,
each designed to latch onto a specific type of microRNA. By exposing blood
samples or purified RNA to these particles, the researchers can generate a
microRNA profile that reveals whether cancer is present. Each type of cancer —
lung, pancreas, and so forth — has its own microRNA signature.

MicroRNAs, which are usually only about 20 nucleotides long, have been
implicated in many other diseases, including HIV, Alzheimer’s disease,
diabetes and cardiovascular disease. The human genome contains about 1,000
microRNAs, believed to fine-tune gene expression by blocking the messenger-RNA
molecules that carry DNA’s protein-building ...

MIT

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